Enzymatic reactions were developed to convert 19 phenolic derivatives containing halogen, nitro, and methyl substituents into eight D-luciferin analogues.
Since the industrial revolution, the rapid growth and development of global industries have depended largely upon the utilization of coal-derived chemicals, and more recently, the utilization of petroleum-based chemicals.
An efficient and green method is presented for the synthesis of esters using carboxylic acid reductase as a biocatalyst under mild aqueous conditions.
The nicotinamide biomimetic BNAH has been demonstrated to serve as an effective reductant for generating reduced flavin in the chemoenzymatic cascade reaction of bacterial luciferase.
The nicotinamide biomimetic BNAH has been demonstrated to serve as an effective reductant for generating reduced flavin in the chemoenzymatic cascade reaction of bacterial luciferase.
https://doi.org/10.1002/cbic.202000100
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The flavin‐dependent monooxygenase, HadA, catalyzes the dehalogenation and denitration of the toxicants, nitro‐ and halogenated phenols, to benzoquinone.
https://doi.org/10.1002/anie.201904923
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Enzymes that are capable of detoxifying halogenated phenols (HPs) and nitrophenols (NPs) are valuable for bioremediation and waste biorefining.
https://doi.org/10.1039/C8SC01482E
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Trihydroxyphenolic acids such as 3,4,5-trihydroxycinnamic acid (3,4,5-THCA) 4c and 2-(3,4,5-trihydroxyphenyl)acetic acid (3,4,5-THPA) 2c are strong antioxidants that are potentially useful as medicinal agents.
https://doi.org/10.1021/acscatal.5b00439
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